![]() ![]() Sublobar resection was more frequently performed in patients who were elder, had more comorbidities and smaller, left-sided adenocarcinoma (P75 years, at pathologic stage I, and those who smoking or undergoing video-assisted thoracoscopic surgery (VATS) or segmentectomy and lobectomy.Ĭonclusions: Sublobar resection was associated with significantly better perioperative outcomes without compromising short term survival in elderly patients with clinical stage I NSCLC. Results: Among the 1,579 eligible patients, 1,164 (73.7%) underwent lobectomy and 415 (26.3%) underwent sublobar resection (106 segmentectomy and 309 wedge resection). Subgroup analysis was further carried out to explore the potential sources of heterogeneity. Perioperative outcomes and overall survival were analyzed by using propensity score matching to adjust for selection bias. Clinical data on demographic and tumor characteristics, surgical details were collected. Clinical stage I NSCLC patients who underwent lobar or sublobar resection (segmentectomy and wedge resection) at the Department of Thoracic Surgery of 10 tertiary hospitals between January 2014 and September 2017 were retrospectively reviewed from the national collaborative prospective lung cancer database (LinkDoc Technology Co, Ltd., Beijing, China). Methods: This is a multicenter retrospective cohort study. lobectomy for management of elderly patients (≥65 years) with clinical stage I NSCLC. The present study aimed to comparatively study the perioperative outcomes and overall survival of sublobar resection vs. However, controversy remains as to whether it is adequate for elderly patients. Zhenrong Zhang 1, Hongxiang Feng 1, Heng Zhao 2, Jian Hu 3, Lunxu Liu 4, Yang Liu 5, Xiaofei Li 6, Lin Xu 7,8, Yin Li 9, Xike Lu 10, Xiangning Fu 11, Haiying Yang 12, Deruo Liu 1ġDepartment of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China 2Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai 200030, China 3Department of Thoracic Surgery, First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310000, China 4Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China 5Department of Thoracic Surgery, Chinese People’s Liberation Army General Hospital, Beijing 1000853, China 6Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China 7Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing 210009, China 8Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing 210009, China 9Department of Thoracic Surgery, Henan Cancer Hospital, Zhengzhou 450008, China 10Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300051, China 11Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 12Medical Affairs, LinkDoc Technology Co, Ltd., Beijing 100080, ChinaĬontributions: (I) Conception and design: D Liu, Z Zhang, H Feng (II) Administrative support: D Liu, Z Zhang, H Feng (III) Provision of study materials or patients: All authors (IV) Collection and assembly of data: All authors (V) Data analysis and interpretation: D Liu, Z Zhang, H Feng, H Yang (VI) Manuscript writing: All authors (VII) Final approval of manuscript: All authors.īackground: Sublobar resection has emerged as an alternative to lobectomy for management of early-stage non-small cell lung cancer (NSCLC). Policy of Dealing with Allegations of Research Misconduct. ![]() Policy of Screening for Plagiarism Process. ![]()
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